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FLASH GENE
Symbol TIMM8A contributors: mct - updated : 24-12-2013
HGNC name translocase of inner mitochondrial membrane 8 homolog A (yeast)
HGNC id 11817
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a largely alpha-helical structure, one on the N terminal region terminated by two cysteine residues, one central comprising two cysteine residues
  • a third one and separated from each other by random coil and suggesting a hairpin of helices held together by the cysteine coodination of the Zn2+ ion
    • conjugated
    HOMOLOGY
    interspecies ortholog to murine Timm8a
    homolog to yeast,translocase of inner mitochondrial protein 8,A
    ortholog to yeast S.cerevisiae Tim8p
    intraspecies paralog to TIM8B
    Homologene
    FAMILY
  • mitochondrial intermembrane proteins family
    • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,interspace
    text intermembrane transport in mitochondria
    basic FUNCTION
  • involved in the import of metabolite transporters from the cytoplasm into the mitochondrial inner membrane
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system , mitochondrial transport , neurogenesis
    text putatively involved in neurologic development
    PATHWAY
    metabolism
    signaling
    a component
  • component of the TIM complex
  • TIM22 protein import pathway consists of two intermembrane space chaperone complexes, the TIMM9-TIMM10 and TIMM8A-TIMM13 complexes (Hasson 2010)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interactig with SLC25A12 and SLC25A13 (substrates for the TIMM8A/TIMM13 complex)
  • interacting with STAM in the cytoplasm or at the mitochondrial outer membrane
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ADS , JS , DDOA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS