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FLASH GENE
Symbol DRP2 contributors: mct - updated : 13-04-2016
HGNC name dystrophin related protein 2
HGNC id 3032
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a WW domain
  • two spectrin repeats
  • a ZZ-type zinc finger
    • HOMOLOGY
    interspecies ortholog to murine Drp2
    homolog to C.elegans C04F12.1
    intraspecies homolog to Apo-dystrophin 2 (Dp116)
    homolog to dystrophin protein 2
    Homologene
    FAMILY
  • dystrophin family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    basic FUNCTION
  • playing a critical role in the maintenance of membrane-associated complexes at points of intercellular contact in vertebrate cells
  • involved in membrane-cytoskeleton interactions of the central nervous system
  • DRP2 and periaxin form Cajal bands with dystroglycan but have distinct roles in Schwann cell growth
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text central nervous system development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • PRX-DRP2 interaction is also required for DRP2 phosphorylation, but phosphorylation is not required for the assembly of appositions
  • DRP2 interacts with PRX and dystroglycan to form the PRX-DRP2-dystroglycan complex which plays a role in the maintenance of the well-characterized Cajal bands of myelinating Schwann cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene may be considered as novel autism candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Drp2-null Schwann cells have disrupted appositions and Cajal bands, and they undergo focal hypermyelination and concomitant demyelination