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FLASH GENE

Symbol

DRP2

contributors: mct - updated : 13-04-2016

HGNC name	dystrophin related protein 2
HGNC id	3032

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	44.55 kb     24 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001939 24 - 7118 NP_001930 108 957 - 2007 17851739 NM_001171184 22 - 5835 NP_001164655 - 879 - 2007 17851739

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain           spinal cord         reproductive epididymis       lowly Reproductive female system ovary     lowly   male system testis     lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a WW domain
	two spectrin repeats
	a ZZ-type zinc finger

HOMOLOGY

interspecies	ortholog to murine Drp2
	homolog to C.elegans C04F12.1

intraspecies	homolog to Apo-dystrophin 2 (Dp116)
	homolog to dystrophin protein 2

Homologene

FAMILY

dystrophin family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION

plasma membrane,junction

basic FUNCTION	playing a critical role in the maintenance of membrane-associated complexes at points of intercellular contact in vertebrate cells
	involved in membrane-cytoskeleton interactions of the central nervous system
	DRP2 and periaxin form Cajal bands with dystroglycan but have distinct roles in Schwann cell growth

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development , nervous system

text	central nervous system development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein	PRX-DRP2 interaction is also required for DRP2 phosphorylation, but phosphorylation is not required for the assembly of appositions
	DRP2 interacts with PRX and dystroglycan to form the PRX-DRP2-dystroglycan complex which plays a role in the maintenance of the well-characterized Cajal bands of myelinating Schwann cells

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	may be considered as novel autism candidate gene
Marker
Therapy target

ANIMAL & CELL MODELS

Drp2-null Schwann cells have disrupted appositions and Cajal bands, and they undergo focal hypermyelination and concomitant demyelination