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FLASH GENE

Symbol

GPM6B

contributors: - updated : 04-11-2006

HGNC name	glycoprotein M6B
HGNC id	4461

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 3 - splicing 1679 29 265 - Narayanan variant 4 - splicing 1533 - 246 - Narayanan,Olinsky variant 2 - splicing 1799 - 305 - Olinsky variant 1 - splicing 3219 - 328 - Olinsky

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear inner cochlea   highly Nervous brain hindbrain cerebellum       brain       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	dorsal root ganglia

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine Gpm6

intraspecies	homolog to PLP,strongly
	homolog to myelin proteolipid protein

Homologene

FAMILY

myelin proteolipid protein family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

playing a role in neuronal development and in myelination

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development , nervous system , detoxification

text	neurogenesis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

M6B2 is regulated intracellulary by phosphorylation during CNS development

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS