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FLASH GENE

Symbol

GPC3

contributors: mct - updated : 25-10-2016

HGNC name	glypican 3
HGNC id	4451

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SGBS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in mesothelioma, breast and ovarian cancer tumoral     --over   in hepatocellular carcinoma (HCC), neuroblastoma and Wilm's tumor cells tumoral     --low   in intrahepatic chanlangiocarcinoma

Susceptibility

Variant & Polymorphism

Candidate gene	specific immunomarker for HCC that can be used to distinguish HCC from benign hepatocellular mass lesions, particularly hepatocellular adenoma , but combination of AFP and GPC3 can elevate the sensitivity of diagnosis
	may have future application as a biomarker for rhabdomyosarcomas
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive liver anti-glypican 3 antibody against the C-terminal 30-kDa fragment such as GC33 are useful in therapy targeting hepatocellular carcinoma cancer muscle   may be a therapeutic target in rhabdomyosarcomas (RMS), the most common paediatric soft tissue sarcomas

ANIMAL & CELL MODELS

Gpc3-deficient mice display a high incidence of congenital cardiac malformations like ventricular septal defects, common atrioventricular canal and double outlet right ventricle