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FLASH GENE
Symbol PLXNA3 contributors: mct - updated : 30-08-2017
HGNC name plexin A3
HGNC id 9101
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Sema domain
  • four IPT/TIG domains
  • a large distinctive cytoplasmic domain
  • N- and C-terminal portions of the GAP homologous regions together form a GAP domain with an overall fold similar to other Ras GAPs
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Plxna3 (94.5 pc)
    homolog to murine Plxna3 (94.5 pc)
    intraspecies homolog to the hepatocyte growth factor receptor family
    Homologene
    FAMILY
  • calcium-dependent cell adhesion molecule family
  • plexin family
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • single-pass type I membrane protein
    • basic FUNCTION
  • involved in the development of neural and epithelial tissues
  • PLXNA3 and plexin-A4 are essential for normal sympathetic development
  • PLXNA3, PLXNA4 convey semaphorin signals during facial nerve development
  • is expressed in oligodendrocyte precursor cell (OPCs) and immature oligodendrocytes and is involved in OPC migration
  • intersection of spontaneous electrical activity with the PLXNA3 guidance molecule receptor in regulation of axon pathfinding
  • PLXNA3 signaling is modulated by spontaneous Ca2+ spike activity-dependent competition
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • involved in SEMA3F-mediated oligodendrocyte precursor cell migration
  • interaction of KCNJ2 and PLXNA3
  • NRCAM stabilizes binding between NRP2 and PLXNA3 necessary for SEMA3F-induced spine pruning
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS