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FLASH GENE

Symbol

PLXNA3

contributors: mct - updated : 30-08-2017

HGNC name	plexin A3
HGNC id	9101

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly Nervous brain       predominantly Homo sapiens Reproductive female system breast mammary gland   moderately   female system ovary     moderately Respiratory lung       moderately   respiratory tract larynx     moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     moderately Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Nervous oligodendrocyte Homo sapiens Fetal Nervous oligodendrocyte Homo sapiens Adult

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a Sema domain
	four IPT/TIG domains
	a large distinctive cytoplasmic domain
	N- and C-terminal portions of the GAP homologous regions together form a GAP domain with an overall fold similar to other Ras GAPs

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to rattus Plxna3 (94.5 pc)
	homolog to murine Plxna3 (94.5 pc)

intraspecies

homolog to the hepatocyte growth factor receptor family

Homologene

FAMILY	calcium-dependent cell adhesion molecule family
	plexin family

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
text	single-pass type I membrane protein

basic FUNCTION	involved in the development of neural and epithelial tissues
	PLXNA3 and plexin-A4 are essential for normal sympathetic development
	PLXNA3, PLXNA4 convey semaphorin signals during facial nerve development
	is expressed in oligodendrocyte precursor cell (OPCs) and immature oligodendrocytes and is involved in OPC migration
	intersection of spontaneous electrical activity with the PLXNA3 guidance molecule receptor in regulation of axon pathfinding
	PLXNA3 signaling is modulated by spontaneous Ca2+ spike activity-dependent competition

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	involved in SEMA3F-mediated oligodendrocyte precursor cell migration
	interaction of KCNJ2 and PLXNA3
	NRCAM stabilizes binding between NRP2 and PLXNA3 necessary for SEMA3F-induced spine pruning

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS