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FLASH GENE
Symbol GUCY2F contributors: mct/npt - updated : 30-08-2021
HGNC name guanylate cyclase 2F, retinal
HGNC id 4691
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extracellular ligand-binding domain
  • one transmembrane segment
  • an intracellular tail with a protein-kinase-like and a catalytic domains
    • HOMOLOGY
    interspecies homolog to murine Gucyf
    Homologene
    FAMILY
  • adenylyl cyclase class-4/guanylyl cyclase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    intracellular,nuclear envelope,ext
    text nuclear outer membrane
    basic FUNCTION
  • photoreceptor membrane guanylyl cyclase regulated by the Ca2+-binding protein GUCA1B
  • both native GUCY2D, and GUCY2F isozymes are important for cGMP synthesis in photoreceptors
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with GUCA1B cooperatively with high affinity
  • RD36 colocalizes and binds to GUCY2D and GUCY2F and plays a crucial role in their stable expression and membrane trafficking in rod and cone photoreceptors
  • both GUCA1A and GUCA1B stimulate GUCY2F equally well at saturation
  • GUCY2D, GUCY2F interaction with RD3 inhibits GC catalytic activity and promotes the exit of GUCY2D, GUCY2F from the endoplasmic reticulum and their trafficking to photoreceptor outer segments
    • cell & other
    REGULATION
    Other regulated by small Ca(2+)-binding proteins named GC-activating proteins that operate as Ca2+ sensors and enable cyclases to respond to changes of intracellular Ca2+ after illumination
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in breast, lung, and pancreatic cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS