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FLASH GENE

Symbol

GUCY2F

contributors: mct/npt - updated : 30-08-2021

HGNC name	guanylate cyclase 2F, retinal
HGNC id	4691

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
STRUCTURE	110.02 kb     20 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001522 20 - 3728 NP_001513 125 1108 - 2007 17868328

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Visual eye

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	extracellular ligand-binding domain
	one transmembrane segment
	an intracellular tail with a protein-kinase-like and a catalytic domains

HOMOLOGY

interspecies

homolog to murine Gucyf

Homologene

FAMILY

adenylyl cyclase class-4/guanylyl cyclase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,nucleus
	intracellular,nuclear envelope,ext
text	nuclear outer membrane

basic FUNCTION	photoreceptor membrane guanylyl cyclase regulated by the Ca2+-binding protein GUCA1B
	both native GUCY2D, and GUCY2F isozymes are important for cGMP synthesis in photoreceptors

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interact with GUCA1B cooperatively with high affinity
	RD36 colocalizes and binds to GUCY2D and GUCY2F and plays a crucial role in their stable expression and membrane trafficking in rod and cone photoreceptors
	both GUCA1A and GUCA1B stimulate GUCY2F equally well at saturation
	GUCY2D, GUCY2F interaction with RD3 inhibits GC catalytic activity and promotes the exit of GUCY2D, GUCY2F from the endoplasmic reticulum and their trafficking to photoreceptor outer segments

cell & other

REGULATION

Other

regulated by small Ca(2+)-binding proteins named GC-activating proteins that operate as Ca2+ sensors and enable cyclases to respond to changes of intracellular Ca2+ after illumination

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       in breast, lung, and pancreatic cancers

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS