| Symbol
| XIAP
| contributors: shn/mct - updated : 19-10-2019
|
| HGNC name
| X-linked inhibitor of apoptosis
|
| HGNC id
| 592
|
| corresponding disease(s)
|
XLP2
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
| |
in hepatocellular carcinoma | | tumoral
|
| deletion
|
|
| |
in X-linked lymphoproliferative syndrome, and in patients with low numbers of natural killer T-lymphocytes (NKT cells) | | constitutional
|
|
| --low
|
| |
renders cells highly sensitive to oxidative stress | | tumoral
|
|
| --over
|
|
in the majority of non-small cell lung carcinoma, together with the abundant or upregulated expression of HBXIP and BIRC5 suggest that tumours are endowed with resistance against a variety of apoptosis-inducing conditions  | | tumoral
|
|
| --over
|
| |
overexpression of FOXM1, XIAP, and BIRC5 contributes to the development of drug-resistance and is associated with poor clinical outcome in breast cancer patients | |
Variant & Polymorphism
| 
| |
Candidate gene
Marker
Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| cancer | digestive | liver | |
| for gene therapy in hepatocellular carcinoma (inhibition of the NF-kappaB/XIAP signaling pathway might selectively abolish the pro-oncogenic activity of TGF-beta1 in advanced hepatocellular carcinomas without affecting the pro-apoptotic effects of TGF-bet | | cancer | | | |
| inhibition as a treatment for malignancy | | cancer | digestive | colon | |
| targeting CFLAR and BIRC4 may represent a therapeutic strategy for the treatment of colorectal tumors with defects in mitochondrial-regulated apoptosis | | cardiovascular | | | |
| may be target protein for the prevention of cardiovascular disease | | cancer | | | |
| potential utilization of XIAP as a target for cancer prevention and therapy | | cancer | endocrine | thyroid | |
| XIAP inhibitor can be therapeutically targeted, either alone or in combination, to induce efficient apoptosis in PTC with overexpression of XIAP |
| | | |
|
| mice deficient in Xiap gene were viable, histopathological analysis did not reveal any differences between IAP-deficient and wild-type mice and any defects in induction of caspase-dependent or -independent apoptosis in cells was found |