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FLASH GENE

Symbol

NAP1L2

contributors: npt/ - updated : 17-06-2005

HGNC name	nucleosome assembly protein 1-like 2
HGNC id	7638

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	2.53 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	cytosine-phosphate-guanine/HTF
	Binding site
text structure	one cpG island and numerous sites for the transcription factors (PBX1)

MAPPING

cloned

Y

linked

status

provisional

regionally located

centromeric to XIST

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_021963 1 - 2559 NP_068798 - 460 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       specific

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

ortholog to murine Bpx

intraspecies

paralog to NAP1Ls

Homologene

FAMILY

nucleosome assembly protein 1 (NAP1) family

CATEGORY

regulatory , structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	regulating neural cell proliferation with chromatin
	play overlapping roles in transport and deposition of histone H2A-H2B or H2A variants-H2B dimers on chromatin and nonoverlapping roles in nucleosome disassembly (Okuwaki 2010)

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding to chromatin

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to neural tube defects

Variant & Polymorphism SNP

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS