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FLASH GENE
Symbol NAP1L2 contributors: npt/ - updated : 17-06-2005
HGNC name nucleosome assembly protein 1-like 2
HGNC id 7638
Location Xq13.2      Physical location : 72.432.154 - 72.434.684
Synonym name
  • brain specific gene BPX
  • brain-specific protein, X-linked
    • Synonym symbol(s) BPX, MGC26243
    DNA
    TYPE functioning gene
    STRUCTURE 2.53 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    Binding site
    text structure one cpG island and numerous sites for the transcription factors (PBX1)
    MAPPING cloned Y linked   status provisional
    regionally located centromeric to XIST
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2559 - 460 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   specific
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Bpx
    intraspecies paralog to NAP1Ls
    Homologene
    FAMILY
  • nucleosome assembly protein 1 (NAP1) family
    • CATEGORY regulatory , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • regulating neural cell proliferation with chromatin
  • play overlapping roles in transport and deposition of histone H2A-H2B or H2A variants-H2B dimers on chromatin and nonoverlapping roles in nucleosome disassembly (Okuwaki 2010)
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to chromatin
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to neural tube defects
    Variant & Polymorphism SNP
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS