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FLASH GENE
Symbol FAM3A contributors: mct - updated : 06-07-2015
HGNC name family with sequence similarity 3, member A
HGNC id 13749
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
hydrophobic leader sequence
HOMOLOGY
interspecies homolog to murine Oit1
Homologene
FAMILY
  • 2-19 family
  • FAM3 family
  • cytokine-like gene family
    • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    intracellular,cytoplasm,organelle,mitochondria
    text
  • secreted
  • mainly localized in the mitochondria, where it increases adenosine triphosphate (ATP) production and secretion in cultured hepatocytes
  • subcellularly located in mitochondria, where it affects ATP production and release
    • basic FUNCTION
  • plays crucial roles in the regulation of glucose and lipid metabolism in the liver, where it activates the PIK3CA-AKT1 signaling pathway by way of a Ca(2+) /CALM1-dependent mechanism
  • FAM3A activates AKT1 in a PIK3CA-dependent manner, but induces ERK1/2 activation independent of PIK3CA
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a novel target gene of PPARG (upregulation of FAM3A by PPARG activation is correlated with increased AKT1 level in liver cells)
  • promotes proliferation and migration of VSMCs via P2RY1 receptor-mediated activation of AKT1 and ERK1/2 pathways
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS