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FLASH GENE

Symbol

FAM3A

contributors: mct - updated : 06-07-2015

HGNC name	family with sequence similarity 3, member A
HGNC id	13749

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel artery     highly Rattus norvegicus Digestive intestine large intestine colon   highly   intestine small intestine     highly   liver       moderately Endocrine pancreas       moderately Reproductive female system ovary     highly   female system uterus cervix   highly   male system prostate     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly Epithelial barrier/lining endothelium     Muscular smooth vessel     Rattus norvegicus

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

brain

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains

hydrophobic leader sequence

HOMOLOGY

interspecies

homolog to murine Oit1

Homologene

FAMILY	2-19 family
	FAM3 family
	cytokine-like gene family

CATEGORY

signaling cytokine

SUBCELLULAR LOCALIZATION	extracellular
	intracellular,cytoplasm,organelle,mitochondria
text	secreted
	mainly localized in the mitochondria, where it increases adenosine triphosphate (ATP) production and secretion in cultured hepatocytes
	subcellularly located in mitochondria, where it affects ATP production and release

basic FUNCTION	plays crucial roles in the regulation of glucose and lipid metabolism in the liver, where it activates the PIK3CA-AKT1 signaling pathway by way of a Ca(2+) /CALM1-dependent mechanism
	FAM3A activates AKT1 in a PIK3CA-dependent manner, but induces ERK1/2 activation independent of PIK3CA

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	is a novel target gene of PPARG (upregulation of FAM3A by PPARG activation is correlated with increased AKT1 level in liver cells)
	promotes proliferation and migration of VSMCs via P2RY1 receptor-mediated activation of AKT1 and ERK1/2 pathways

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS