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FLASH GENE

Symbol

TAZ

contributors: mct/npt/pgu - updated : 27-11-2017

HGNC name	tafazzin
HGNC id	11577

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CMD3A , BTHS , INVM

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   inhibited adipogenesis and promoted the trans-differentiation of preadipocytes into osteocytes ( tumoral     --other   aberrantly expressed in some cancers, including rectal cancer and thyroid neoplasms tumoral     --over   in cervical cancer and may promote tumorigenicity of cervical cancer cells and inhibit apoptosis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     networking between TAZ and TJP1 and TJP2 offers a promising target in the control of proliferation and apoptosis, epithelial-mesenchymal transition and migration capacity of cancer cells

ANIMAL & CELL MODELS

	defects of cardiac mitochondria and mitochondrion-associated membranes in taz-deficient mice, and cardiac muscle and skeletal muscle of tafazzin-deficient mice demonstrate ultrastructural defects, including mitochondrial proliferation, myofibrillar disarray, mitophagy
	Tafazzin-knockdown in mice markedly impaired oxygen consumption rates during an exercise, without any significant effect on resting metabolic rates
	Taz deficiency in mouse embryonic fibroblasts (MEFs) also led to impaired oxidative phosphorylation and severe oxidative stress