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| overexpression of MeCP2 in the mouse heart causes embryonic lethality with cardiac septum hypertrophy and dysregulated expression of MeCP2 in skeletal tissue produces severe malformations  | |
mice bearing a hypomorphic mutation in Mecp2 display altered behavioral responses to acute and repeated AMPH treatment and changes in both the development and plasticity of striatal synapses |
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in globally MeCP2-deficient mice, re-expression of Mecp2 preferentially in astrocytes significantly improved locomotion and anxiety levels, restored respiratory abnormalities to a normal pattern, and greatly prolonged lifespan compared to globally null mice |
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neuron-specific deletion of MeCP2 recapitulates the RTT symptoms of the whole-body KO mouse, implicating an essential role for MeCP2 in neurons |
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decreased dopamine transmission due to heterogeneous Mecp2 expression contributes to the parkinsonian features of RTT in Mecp2(+/-) mice |
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mutations occurring in Rett patients are defective in the chromatin architecture function of MeCP2 |
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cholesterol homeostasis is disrupted in Mecp2 mutant mice |
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loss of MECP2 causes mislocalization of the ATRX in the hippocampus and cortex of symptomatic KO mice |