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FLASH GENE

Symbol

STS

contributors: mct/npt - updated : 27-01-2010

HGNC name	steroid sulfatase (microsomal), isozyme S
HGNC id	11425

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland         Reproductive female system placenta     highly   female system ovary         male system testis       Respiratory respiratory tract larynx     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

trypsin domain

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

sulfatase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,organelle,lysosome
	intracellular,cytoplasm,cytosolic,microsome
	intracellular,nuclear envelope
text	membrane-bound microsomal (Valle 2007)

basic FUNCTION	desulphating a number of 3beta-hydroxysteroid sulphates
	catalyzing the conversion of sulfated steroid precursors to estrogens during pregnancy
	playing a crucial role in the intra-mitochondrial movement of cholesterol
	may play a role in susceptibility for attention deficit hyperactivity disorder (Brookes 2008)
	membrane-bound microsomal enzyme that hydrolyzes various alkyl and aryl steroid sulfates (Nardi 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	binds 1 calcium ion per subunit

protein

increasing STAR protein expression level and stimulating steroid production

cell & other

REGULATION

activated by

thyroid hormones

ASSOCIATED DISORDERS

corresponding disease(s)

SSDI , DELXPM

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in endometrial carcinomas

Susceptibility

to attention deficit hyperactivity disorder (Brookes 2008)

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS