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FLASH GENE

Symbol

PLP1

contributors: mct - updated : 20-01-2015

HGNC name	proteolipid protein 1
HGNC id	9086

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	myelin-deficient (MD) rats, which carry a mutation in the Plp gene, exhibit lethal hypoxic ventilatory depression
	lowering toxic Plp1 overexpression via a progesterone antagonist ameliorates axonal loss and the disease phenotype in Plp1 transgenic mice
	mice with Plp1 gene duplication model the most common form of Pelizaeus-Merzbacher disease (PMD), a CNS disease in which patients may suffer respiratory complications