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FLASH GENE
Symbol PHKA1 contributors: mct - updated : 03-02-2017
HGNC name phosphorylase kinase, alpha 1 (muscle)
HGNC id 8925
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal glucoamylase-like domains
    • HOMOLOGY
    interspecies homolog to murine Phka1
    intraspecies homolog to PHDA2
    Homologene
    FAMILY phosphorylase type b kinase regulatory chain family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in the regulation of glycogen breakdown
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NFE2L2 induction in skeletal muscle (SkM) increases GBE1 and PHKA1 expression and reduces muscle glycogen content, resulting in improved glucose tolerance
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GSD5B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS