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FLASH GENE

Symbol

PGK1

contributors: mct/npt - updated : 17-06-2020

HGNC name	phosphoglycerate kinase 1
HGNC id	8896

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	22.66 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	cen - DXZ1 - PGK1P1 - DXS1 - DXS159 - DXS153 - GJB1 - TAF1 - DXS131 ,DXS162 - PHKA1 - DXS227 - XIST ,DXS128 - DXS441 - DXS171 - DXS347 - DXS325 - DXS356 - DXS56 - MNK - PGK1P1 - DXS346 ,DXS447 - DXS72 - qter
Authors	Lafrenière (91), Consensus (93)
Text	see ED1 , GJB1

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000291 11 - 2439 NP_000282 - 417 - 2019 31492635

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     moderately Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Reproductive spermatogonia Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

monomer

HOMOLOGY

interspecies

homolog to murine Pgk1

Homologene

FAMILY

phosphoglycerate kinase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	phosphoglycerate kinase involved in glycolysis
	key enzyme for ATP generation and energy pathway
	might be a potential protein biomarker of intracellular oxidative status (Jang 2008)
	PGK1 and PGK2 are involved in spermatogenesis and thought to be related to sperm motility
	important dual roles of PGK1 as a glycolytic enzyme and a protein kinase in the mutual regulation of cell metabolism and autophagy in maintaining cell homeostasis
	PGK1 catalyzes the reversible transfer of a phosphate group from 1,3-bisphosphoglycerate to ADP and produces 3-phosphoglycerate and ATP

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	CDC7-bound PGK1 converts ADP to ATP, thereby abrogating the inhibitory effect of ADP on CDC7-ASK activity, promoting the recruitment of DNA helicase to replication origins, DNA replication, cell proliferation, and brain tumorigenesis
	protein phosphatase activity of PTEN dephosphorylates and inhibits autophosphorylated PGK1, thereby inhibiting glycolysis, ATP production, and brain tumor cell proliferation

cell & other

REGULATION

induced by

hydrogen peroxide

ASSOCIATED DISORDERS

corresponding disease(s)

PGK1D

related resource

Retinal Information Network

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   decreased in the testis with ageing tumoral     --over   leads to tumor cell proliferation tumoral     --over   is associated with poor prognosis in breast cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may serve as a promising biomarker for breast cancer
Therapy target
	System Type Disorder Pubmed cancer reproductive breast may serve as a promising target therapy for breast cancer

ANIMAL & CELL MODELS