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FLASH GENE
Symbol CFP contributors: mct - updated : 29-11-2017
HGNC name complement factor properdin
HGNC id 8864
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • modular protein with distinct N and C terminal region
  • a central region
  • six tandem repeated motifs, related to the type I repeat sequence of thrombospondin
    • conjugated GlycoP
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • thrombospondin family
    • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • complement alternative pathway
  • stabilizing the alternative pathway C3 convertase
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MPO binds properdin directly, which then serves as a focus for alternative pathway (AP) activation
    • cell & other
  • can directly interact with neutrophil components
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PFD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS