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FLASH GENE

Symbol

CFP

contributors: mct - updated : 29-11-2017

HGNC name	complement factor properdin
HGNC id	8864

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed CFP 10 - 1701 51 469 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	modular protein with distinct N and C terminal region
	a central region
	six tandem repeated motifs, related to the type I repeat sequence of thrombospondin

conjugated

GlycoP

mono polymer

monomer

HOMOLOGY

Homologene

FAMILY

thrombospondin family

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION

basic FUNCTION	complement alternative pathway
	stabilizing the alternative pathway C3 convertase

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

MPO binds properdin directly, which then serves as a focus for alternative pathway (AP) activation

cell & other

can directly interact with neutrophil components

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PFD

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS