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	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

PDHA1

contributors: mct/npt - updated : 06-07-2022

HGNC name	pyruvate dehydrogenase (lipoamide) alpha 1
HGNC id	8806

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

PDHA1D , LGS

related resource

MITOP database

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   promotes cancer progression and acts as a poor prognostic factor for cancer tumoral     --low   significantly correlated with a poorer overall survival in patients with Gastric cancer constitutional     --low   significantly decreased in the putamen and substantia nigra of patients with idiopathic Parkinson disease

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	decreased expression of PDHA1 might be an independent prognostic factor in unfavorable outcomes in ovarian carcinoma
	PDHA1 is an independent predictor of overall survival in Gastric cancer
Therapy target

ANIMAL & CELL MODELS