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FLASH GENE
Symbol TBC1D25 contributors: mct - updated : 25-10-2011
HGNC name TBC1 domain family, member 25
HGNC id 8092
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a TBC domain
HOMOLOGY
interspecies ortholog to murine Oatl1
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • functioning as a Rab GTPase activating protein
  • recruited to isolation membranes and autophagosomes through direct interaction with GABARAPL2 homologues and is involved in the fusion between autophagosomes and lysosomes through its GAP activity
  • involved in the fusion between autophagosomes and lysosomes through its GAP activity and its GABARAPL2 homolog binding activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB33B is a target substrate of TBC1D25 and is involved in the fusion between autophagosomes and lysosomes, the same as TBC1D25
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS