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FLASH GENE
Symbol TBC1D25 contributors: mct - updated : 25-10-2011
HGNC name TBC1 domain family, member 25
HGNC id 8092
Location Xp11.23      Physical location : 48.398.074 - 48.420.997
Synonym name
  • ornithine aminotransferase-like 1
  • MG81 protein
  • Synonym symbol(s) OATP1, MG81, MGC126868, MGC126866, OATL1
    DNA
    TYPE functioning gene
    STRUCTURE 22.92 kb     6 Exon(s)
    MAPPING cloned Y linked Y status confirmed
    Map pter - DXS228 - DXS7 - UBE1 - DXS1055 - DXS1003 - DXS1146 - DXS1266 - ARAF ,SYN1 ,TIMP1 - PFC - (DXS426 ,ELK1 ),ZNF41 - ZNF81 - DXS6849 - ZNF21 - DXS1265 - DXS1267 - (TBC1D25 ,DXS6950 - DXS6949 ) - DXS722 - WAS ,DXS1011E ,DXS7467 - DXS1358 - GATA1 - DXS226 - ERAS - DXS1126 - DXS1240 - DXS1011E ,DXS1470 - TFE3 - DXS576 ,LMO6 - SYP - DXS573 - DXS1039 - DXS255 - CLCN5 - DXS146 - OATL2 - DXS14 - cen
    Authors Knight (92), Berger (92), Coleman (93), Knight (94), Coleman (94), Consensus, Willard (94), Boycott (96), Fisher (97)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2227 - 100 - Chand
    6 - 3830 76.3 688 - 2009 19077034
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
     salivary gland   highly
    Hearing/Equilibriumearinnercochlea  
    Reproductivemale systemprostate   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a TBC domain
    HOMOLOGY
    interspecies ortholog to murine Oatl1
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • functioning as a Rab GTPase activating protein
  • recruited to isolation membranes and autophagosomes through direct interaction with GABARAPL2 homologues and is involved in the fusion between autophagosomes and lysosomes through its GAP activity
  • involved in the fusion between autophagosomes and lysosomes through its GAP activity and its GABARAPL2 homolog binding activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB33B is a target substrate of TBC1D25 and is involved in the fusion between autophagosomes and lysosomes, the same as TBC1D25
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS