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FLASH GENE
Symbol MCF2 contributors: - updated : 31-12-2004
HGNC name MCF.2 cell line derived transforming sequence
HGNC id 6940
DNA
TYPE functioning gene
STRUCTURE 60.00 kb     26 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • a pleckstrin homology (PH)
  • a DBL domains and a SH3 domain
  • a RhoGEF domain
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to yeast Cdc24
    intraspecies homolog to Ascidian protein posterior End MARK2 (PEM2)
    Homologene
    FAMILY
    CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • GDP-GTP exchange factor for CDC42HS, specifically activating CDC42 and not RAC or RHOA
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS