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FLASH GENE

Symbol

MAOB

contributors: mct - updated : 03-04-2013

HGNC name	monoamine oxidase B
HGNC id	6834

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MAOA/BD

related resource

MITOP database

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function increased brain MAOB activity is associated with Alzheimer disease constitutional     --low   significantly lower platelet MAOB activity in children with hyperactive, inattentive, and combined subtype of ADHD than in control children

Susceptibility

to Parkinson disease

Variant & Polymorphism

Candidate gene
Marker	MAOB platelet protein level may serve as a biomarker for age-related dementia, especially Alzheimer disease
	increased MAOB protein levels might serve as a surrogate marker for - Parkinson disease
Therapy target

ANIMAL & CELL MODELS