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FLASH GENE
Symbol MAOB contributors: mct - updated : 03-04-2013
HGNC name monoamine oxidase B
HGNC id 6834
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • FAD binding domain
  • anchored to the outer mitochondrial membrane via C-terminal helical tails
    • mono polymer homomer , heteromer , monomer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans C24G6.6
    intraspecies homolog to MAOA
    Homologene
    FAMILY flavin monoamine oxidase family
    CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • degrading amine neurotransmitters
  • catalyzing the oxidative deamination of biogenic and xenobiotic amines and playing an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues
  • novel roles for MAOA, MAOB and serotonin in the regulation of intermediate progenitor cells proliferation in the developing brain
  • PARK2 suppresses the transcription of MAOA, MAOB to control oxidative stress induced by dopamine oxidation
  • MAOA and MAOB are a crucial pair of isoenzymes, which oxidatively deaminate monoamine neurotransmitters and dietary amines with a production of hydrogen peroxide
  • MAOA, and MAOB are dimeric in their membrane-bound forms
  • MAOA and MAOB are mitochondrial-bound proteins, catalyzing the oxidative deamination of monoamine neurotransmitters as well as xenobiotic amines
  • plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism amine , hormone
    signaling neurotransmission
    metabolism of biogenic amine hormones (such as dopamine, serotonin, norepinephrine)
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    FAD
    protein
  • targeting JUN and EGR1 afteractivation by a protein-kinase C MAPK signal transduction pathway
  • PARK2 suppresses the transcription of MAOA, MAOB to control oxidative stress induced by dopamine oxidation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MAOA/BD
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    increased brain MAOB activity is associated with Alzheimer disease
    constitutional     --low  
    significantly lower platelet MAOB activity in children with hyperactive, inattentive, and combined subtype of ADHD than in control children
    Susceptibility to Parkinson disease
    Variant & Polymorphism
    Candidate gene
    Marker
  • MAOB platelet protein level may serve as a biomarker for age-related dementia, especially Alzheimer disease
  • increased MAOB protein levels might serve as a surrogate marker for - Parkinson disease
    • Therapy target
    ANIMAL & CELL MODELS