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FLASH GENE

Symbol

MAOB

contributors: mct - updated : 03-04-2013

HGNC name	monoamine oxidase B
HGNC id	6834

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland       highly Nervous brain           nerve cranial nerve     highly Reproductive female system uterus     highly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic platelet

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	FAD binding domain
	anchored to the outer mitochondrial membrane via C-terminal helical tails

mono polymer

homomer , heteromer , monomer , dimer

HOMOLOGY

interspecies

homolog to C.elegans C24G6.6

intraspecies

homolog to MAOA

Homologene

FAMILY

flavin monoamine oxidase family

CATEGORY

enzyme , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,mitochondria,outer
	intracellular,cytoplasm,organelle,membrane

basic FUNCTION	degrading amine neurotransmitters
	catalyzing the oxidative deamination of biogenic and xenobiotic amines and playing an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues
	novel roles for MAOA, MAOB and serotonin in the regulation of intermediate progenitor cells proliferation in the developing brain
	PARK2 suppresses the transcription of MAOA, MAOB to control oxidative stress induced by dopamine oxidation
	MAOA and MAOB are a crucial pair of isoenzymes, which oxidatively deaminate monoamine neurotransmitters and dietary amines with a production of hydrogen peroxide
	MAOA, and MAOB are dimeric in their membrane-bound forms
	MAOA and MAOB are mitochondrial-bound proteins, catalyzing the oxidative deamination of monoamine neurotransmitters as well as xenobiotic amines
	plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

electron transport

PATHWAY

metabolism

amine , hormone

signaling

neurotransmission

metabolism of biogenic amine hormones (such as dopamine, serotonin, norepinephrine)

a component

INTERACTION

DNA

RNA

small molecule	cofactor, nucleotide,
	FAD

protein	targeting JUN and EGR1 afteractivation by a protein-kinase C MAPK signal transduction pathway
	PARK2 suppresses the transcription of MAOA, MAOB to control oxidative stress induced by dopamine oxidation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MAOA/BD

related resource

MITOP database

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function increased brain MAOB activity is associated with Alzheimer disease constitutional     --low   significantly lower platelet MAOB activity in children with hyperactive, inattentive, and combined subtype of ADHD than in control children

Susceptibility

to Parkinson disease

Variant & Polymorphism

Candidate gene
Marker	MAOB platelet protein level may serve as a biomarker for age-related dementia, especially Alzheimer disease
	increased MAOB protein levels might serve as a surrogate marker for - Parkinson disease
Therapy target

ANIMAL & CELL MODELS