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FLASH GENE
Symbol MAOB contributors: mct - updated : 03-04-2013
HGNC name monoamine oxidase B
HGNC id 6834
Corresponding disease
MAOA/BD MAOA/B deletion syndrome
Location Xp11.23      Physical location : 43.625.857 - 43.741.721
Synonym name
  • amine oxidase (flavin-containing)
  • tyramine oxidase
  • EC.number 1.4.3.4
    DNA
    TYPE functioning gene
    STRUCTURE 115.87 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Physical map
    MKRN4 Xp21.1 makorin, ring finger protein, 4 LOC392447 X similar to 60S ribosomal protein L32 LOC286444 Xp11.4 similar to ribosomal protein S2; 40S ribosomal protein S2 LOC392448 X similar to Chloride intracellular channel protein 4 (mc3s5/mtCLIC) USP9X Xp11.4 ubiquitin specific protease 9, X chromosome (fat facets-like Drosophila) DDX3X Xp11.3-p11.23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked NYX Xp11.4 nyctalopin CASK Xp11.4 calcium/calmodulin-dependent serine protein kinase (MAGUK family) LOC158781 Xp11.4 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene GPR34 Xp11.4-p11.3 G protein-coupled receptor 34 GPR82 Xp11.4 G protein-coupled receptor 82 I-4 Xp11.4-Xp11.3 type 1 protein phosphatase inhibitor LOC139334 Xp11.4 similar to inosine monophosphate dehydrogenase 1 isoform b; sWSS2608 LOC392449 X similar to Nanog homeobox; homeobox transcription factor Nanog LOC389847 X similar to Amine oxidase [flavin-containing] A (Monoamine oxidase) (MAO-A) MAOA Xp11.23 monoamine oxidase A MAOB Xp11.23 monoamine oxidase B NDP Xp11.4 Norrie disease (pseudoglioma) LOC286398 Xp11.4 similar to RNA-binding region containing protein 2 (Hepatocellular carcinoma protein 1) (Splicing factor HCC1) FLJ22843 Xp11.4 hypothetical protein FLJ22843 RRM2P3 Xp21-p11 ribonucleotide reductase M2 polypeptide pseudogene 3 LOC139339 Xp11.4 similar to ubinuclein 1 LOC392450 X similar to Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) MGC51029 Xp11.4 hypothetical protein MGC51029 LOC392451 X similar to hypothetical protein LOC389848 X similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) UTX Xp11.3-p11.23 ubiquitously transcribed tetratricopeptide repeat gene, X chromosome DUSP21 Xp11.4-p11.23 dual specificity phosphatase 21 FLJ14103  hypothetical protein FLJ14103 LOC139061 Xp11.3 similar to plasmolipin LOC347333 Xp11.3 similar to tau tubulin kinase 2; tau-tubulin kinase LOC392452 X similar to RIKEN cDNA 5230400G24 LOC392453 X similar to arginine/serine-rich splicing factor 6; splicing factor, arginine/serine-rich, 55 kDa; pre-mRNA splicing factor SRP55 LOC139060 Xp11.3 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC392454 X similar to Proliferating cell nuclear antigen (PCNA) (Cyclin) PCNAP Xp11 proliferating cell nuclear antigen pseudogene LOC392455 X similar to beta actin LOC392456 X similar to beta catenin-like 1; nuclear associated protein; chromosome 20 open reading frame 33 LOC389849 X similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) FLJ20344 Xp11.3 hypothetical protein FLJ20344 RNU6P1 Xp11.3 RNA, U6 small nuclear pseudogene 1 LOC392457 X similar to Antigen KI-67 CHST7 Xp11.23 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2611 - 520 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Nervousbrain    
     nervecranial nerve  highly
    Reproductivefemale systemuterus  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • FAD binding domain
  • anchored to the outer mitochondrial membrane via C-terminal helical tails
  • mono polymer homomer , heteromer , monomer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans C24G6.6
    intraspecies homolog to MAOA
    Homologene
    FAMILY flavin monoamine oxidase family
    CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • degrading amine neurotransmitters
  • catalyzing the oxidative deamination of biogenic and xenobiotic amines and playing an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues
  • novel roles for MAOA, MAOB and serotonin in the regulation of intermediate progenitor cells proliferation in the developing brain
  • PARK2 suppresses the transcription of MAOA, MAOB to control oxidative stress induced by dopamine oxidation
  • MAOA and MAOB are a crucial pair of isoenzymes, which oxidatively deaminate monoamine neurotransmitters and dietary amines with a production of hydrogen peroxide
  • MAOA, and MAOB are dimeric in their membrane-bound forms
  • MAOA and MAOB are mitochondrial-bound proteins, catalyzing the oxidative deamination of monoamine neurotransmitters as well as xenobiotic amines
  • plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism amine , hormone
    signaling neurotransmission
    metabolism of biogenic amine hormones (such as dopamine, serotonin, norepinephrine)
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    FAD
    protein
  • targeting JUN and EGR1 afteractivation by a protein-kinase C MAPK signal transduction pathway
  • PARK2 suppresses the transcription of MAOA, MAOB to control oxidative stress induced by dopamine oxidation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MAOA/BD
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    increased brain MAOB activity is associated with Alzheimer disease
    constitutional     --low  
    significantly lower platelet MAOB activity in children with hyperactive, inattentive, and combined subtype of ADHD than in control children
    Susceptibility to Parkinson disease
    Variant & Polymorphism
    Candidate gene
    Marker
  • MAOB platelet protein level may serve as a biomarker for age-related dementia, especially Alzheimer disease
  • increased MAOB protein levels might serve as a surrogate marker for - Parkinson disease
  • Therapy target
    ANIMAL & CELL MODELS