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FLASH GENE

Symbol

MAOA

contributors: mct - updated : 19-03-2015

HGNC name	monoamine oxidase A
HGNC id	6833

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MRIB , MAOA/BD

related resource

MITOP database

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in female panic desorders constitutional     --low   significantly lower platelet MAOA activity in children with hyperactive, inattentive, and combined subtype of ADHD than in control children constitutional       loss of function results in high 5-HT levels, antisocial, aggressive, and perseverative behaviors

Susceptibility

to anorexia nervosa and to Parkinson disease to delinquent behavior in adolescence and young adulthood to attention--deficit/hyperactivity disorder (ADHD) to variation of interindividual differences in behavior.

Variant & Polymorphism other	rare 2 repeat of the 30-bp VNTR2, associated with deinquent behavior in adolescence and young adulthood
	status of MAOA methylation observed in healthy males merits consideration as a variable contributing to interindividual differences in behavior
	interaction of MAOA and SYP may be involved in the genetic mechanism of ADHD-I subtype

Candidate gene	for obesity in dupXp11p21 patients
Marker
Therapy target

ANIMAL & CELL MODELS

	Htr6 mediates defective brain development in monoamine oxidase A-deficient mouse embryos
	early postnatal inhibition of serotonin synthesis results in long-term reductions of perseverative behaviors, but not aggression, in Maoa-deficient mice