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FLASH GENE

Symbol

MAOA

contributors: mct - updated : 19-03-2015

HGNC name	monoamine oxidase A
HGNC id	6833

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001270458 16 - 5438 NP_001257387 - 394 - - NM_000240 15 - 5330 NP_001257387 - 394 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid       highly Reproductive female system placenta     highly Respiratory respiratory tract trachea     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	flavin containing amine oxidase domain
	anchored to the outer mitochondrial membrane via C-terminal helical tails

mono polymer

homomer , heteromer , monomer , dimer

HOMOLOGY

interspecies

homolog to rattus Maob

intraspecies

paralog to MAOB

Homologene

FAMILY

flavin monoamine oxidase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,outer
	intracellular,cytoplasm,organelle,membrane

basic FUNCTION	degrading amine neurotransmitters (such as dopamine, norepinephrin and serotonin)
	having important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues
	MAOA, SLC6A2, SLC6A3 may play important roles in regulating maternal monoamine neurotransmitters transferred across the placenta to the fetus
	novel roles for MAOA, MAOB and serotonin in the regulation of intermediate progenitor cells proliferation in the developing brain
	MAOA and MAOB are a crucial pair of isoenzymes, which oxidatively deaminate monoamine neurotransmitters and dietary amines with a production of hydrogen peroxide
	MAOA, and MAOB are dimeric in their membrane-bound forms
	MAOA and MAOB are mitochondrial-bound proteins, catalyzing the oxidative deamination of monoamine neurotransmitters as well as xenobiotic amines
	primarily deaminates serotonin, norepinephrine, and dopamine and, therefore, is implicated in several psychiatric diseases

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

electron transport

PATHWAY

metabolism

amine , hormone

signaling

neurotransmission

	metabolism of various biogenic amine hormones
	glucocorticoid-KLF11-MAOA pathway may play a crucial role in modulating distinct pathophysiological steps in stress-related disorders

a component

INTERACTION

DNA

RNA

small molecule	cofactor, nucleotide,
	FAD

protein	interacting with CDCA7L (inhibits the MAOA promoter and enzymatic activities)
	SLC6A2
	PARK2 suppresses the transcription of MAOA, MAOB to control oxidative stress induced by dopamine oxidation
	KLF11 is an MAOA regulator and is produced in response to neuronal stress, which transcriptionally activates MAOA
	stress increases KLF11 expression and induces its nuclear translocation and contributes to increase in MAOA expression
	GATA2, SP1 and TATA-binding protein (TBP)interacting with the proximal promoter region of MAOA

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MRIB , MAOA/BD

related resource

MITOP database

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in female panic desorders constitutional     --low   significantly lower platelet MAOA activity in children with hyperactive, inattentive, and combined subtype of ADHD than in control children constitutional       loss of function results in high 5-HT levels, antisocial, aggressive, and perseverative behaviors

Susceptibility

to anorexia nervosa and to Parkinson disease to delinquent behavior in adolescence and young adulthood to attention--deficit/hyperactivity disorder (ADHD) to variation of interindividual differences in behavior.

Variant & Polymorphism other	rare 2 repeat of the 30-bp VNTR2, associated with deinquent behavior in adolescence and young adulthood
	status of MAOA methylation observed in healthy males merits consideration as a variable contributing to interindividual differences in behavior
	interaction of MAOA and SYP may be involved in the genetic mechanism of ADHD-I subtype

Candidate gene	for obesity in dupXp11p21 patients
Marker
Therapy target

ANIMAL & CELL MODELS

	Htr6 mediates defective brain development in monoamine oxidase A-deficient mouse embryos
	early postnatal inhibition of serotonin synthesis results in long-term reductions of perseverative behaviors, but not aggression, in Maoa-deficient mice