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| Cerebellar granule neurons expressing a deletion mutant of L1CAM lacking the cytoplasmic domain (hL1-1147) show a reduced branching of neurites ( | |
L1-6D mutant mice, homozygous for a deletion removing the sixth immunoglobulin-like domain of L1cam, seldom display hydrocephalus on the 129/Sv background, while the same L1-6D mutation produces severe hydrocephalus on the C57BL/6J background ( |
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L1cam knockout mice have hydrocephalus, a small cerebellum, hyperfasciculation of corticothalamic tracts, and abnormal peripheral nerves ( |
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Enhanced expression of L1-CAM may contribute to the pain syndrome and perineural invasion and may correlate with poor overall survival in human pancreatic cancer ( |
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L1CD mutant lines that lack the ankyrin-binding region display normal brain morphology but the expression of L1 protein in the adult is dramatically reduced and they show defects in motor function ( |
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L1CAM expression leads to the activation of the nuclear factor (NF)-& |
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954;B pathway, promoting cell proliferation in vitro and metastasis formation in vivo ( |