Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

POLD1

contributors: mct - updated : 23-11-2013

HGNC name	polymerase (DNA directed), delta 1, catalytic subunit 125kDa
HGNC id	9175

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MDPL

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in sporadic colorectal cancer constitutional     --low   mRNA expression of DNA POLD1 decreased substantially with age

Susceptibility

to colorectal adenomas and carcinomas

Variant & Polymorphism other	POLD1 p.Ser478Asn, have high penetrance, and is associated with colorectal adenomas and carcinomas and endometrial cancer predisposition

Candidate gene
Marker	DNA POLD1 has great potential for a new biomarker of aging
Therapy target

ANIMAL & CELL MODELS