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FLASH GENE

Symbol

DBH

contributors: mct - updated : 07-11-2022

HGNC name	dopamine beta-hydroxylase (dopamine beta-monooxygenase)
HGNC id	2689

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

ORTHYP1

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function DBH activity is statistically significantly decreased in non-treated depressive disorder and ADHD in children and adolescents

Susceptibility

to decreased DBH with attention-deficit, hyperactivity disorder to migraine with aura

Variant & Polymorphism SNP , other	SNP 1021C->T

Candidate gene	major QTL for plasma activity
Marker
Therapy target
	System Type Disorder Pubmed miscelleaneous hypertension   potential drug target to combat hypertension

ANIMAL & CELL MODELS

overexpressed in human beta hydroxylase transgenic mice