Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | C5 | contributors: mct/npt - updated : 02-05-2013 |
HGNC name | complement component 5 |
HGNC id | 1331 |
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Corresponding disease |
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Location | 9q33.2 Physical location : 123.714.615 - 123.812.554 | ||
Synonym name | |||
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protein 4 | |||
Synonym symbol(s) | CPAMD4, MGC142298, FLJ17816, FLJ17822 |
DNA |
TYPE | functioning gene |
STRUCTURE | 97.94 kb 41 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cell lineage
cell lines
| fluid/secretion
| plasma | |
at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
| |
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secondary structure | an alpha 2 |
conjugated | GlycoP |
isoforms | Precursor |
HOMOLOGY |
interspecies | ortholog to murine Hc |
ortholog to rattus c5 |
Homologene |
FAMILY |
CATEGORY | immunity/defense |
SUBCELLULAR LOCALIZATION | extracellular |
plasma membrane | |
intracellular | |
intracellular,cytoplasm |
CELLULAR PROCESS | cell communication |
PHYSIOLOGICAL PROCESS | immunity/defense , inflammation |
text | chemotaxis C5a |
PATHWAY |
metabolism |
signaling | signal transduction |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
cell & other |
REGULATION |
inhibited by | inactivated (cleaved) in the classical pathway by the complex C4b,C2a,C3b and in the alternative pathway by the complex C3b,BF |
ASSOCIATED DISORDERS |
corresponding disease(s) | C5 |
related resource | C5base - Mutation registry for C5 deficiency |
Susceptibility |
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ANIMAL & CELL MODELS |