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	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

ASS1

contributors: mct - updated : 11-09-2014

HGNC name	argininosuccinate synthetase 1
HGNC id	758

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CTLN1

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   either low in abundance or absent in breast cancer biosamples constitutional     --low   mRNA level of ASS1 in PKU patients was lower than that of normal people, which was well correlated with its methylation status tumoral     --low   in myxofibrosarcomas, with loss of expression linked to promoter methylation, and clinical aggressiveness

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive breast breast cancer could be candidate for arginine starvation therapy

ANIMAL & CELL MODELS