Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | ASS1 | contributors: mct - updated : 11-09-2014 |
HGNC name | argininosuccinate synthetase 1 |
HGNC id | 758 |
|
RNA |
TRANSCRIPTS | type | messenger |
---|
text | Two transcript variants encoding the same protein |
|
EXPRESSION |
Type | widely |
expressed in | (based on citations) | ||||||||||||||||||||
organ(s) |
|
cells |
|
cell lineage
cell lines
| fluid/secretion
| |
at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
![]() | arginosuccinate synthase motif |
mono polymer | homomer , tetramer |
HOMOLOGY |
interspecies | homolog to murine Ass1 |
Homologene |
FAMILY | |
|
CATEGORY | enzyme |
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism | aminoacid |
signaling | sensory transduction/olfaction |
arginine biosynthetic pathways |
a component |
INTERACTION |
DNA |
RNA |
small molecule | nucleotide, |
ATP |
protein | ![]() |
![]() |
cell & other |
REGULATION |
activated by | laminar shear stress increases the expression of ASS1 that regulates the provision of L-arginine, the substrate of NOS3 ![]() |
induced by | endothelial ASS1 expression was induced by laminar shear stress (LSS) ![]() |
ASSOCIATED DISORDERS |
corresponding disease(s) | CTLN1 |
Susceptibility |
Variant & Polymorphism
![]() |
Candidate gene
Marker
| Therapy target
|
|
|
|
ANIMAL & CELL MODELS |