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FLASH GENE
Symbol ASL contributors: mct/npt - updated : 22-02-2010
HGNC name argininosuccinate lyase
HGNC id 746
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • lyase domain
    • mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to murine Asl
    Homologene
    FAMILY
  • lyase 1 family
  • arginosuccinate lyase subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • urea cycle, the last step in arginine boisynthesis, involved in the disposal of ingested nitrogen
  • catalyzes the cleavage of argininosuccinate to fumarate and arginine, an essential step in the process of detoxification of ammonia via the urea cycle
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism amine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ASL
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS