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FLASH GENE

Symbol

ALAD

contributors: npt/ - updated : 13-11-2006

HGNC name	aminolevulinate, delta-, dehydratase
HGNC id	395

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a catalytic domain

secondary structure

an alpha 1 helix at the N terminus

mono polymer

homomer , dimer , hexamer

HOMOLOGY

interspecies	ortholog to murine Alad
	ortholog to rattus Alad

Homologene

FAMILY

ALADH family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION

catalyzing the condensation of two molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins)

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

porphyrin/heme

signaling

second step of porphyrin and heme biosynthesis

a component

INTERACTION

DNA

RNA

small molecule	metal binding, cofactor,
	Zn2+

protein

cell & other

REGULATION

inhibited by

lead

ASSOCIATED DISORDERS

corresponding disease(s)

ALADD

Susceptibility

to lead poisoning

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS