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FLASH GENE

Symbol

ALDOB

contributors: mct - updated : 28-11-2019

HGNC name	aldolase B, fructose-bisphosphate
HGNC id	417

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000035 9 - 2426 NP_000026 - 364 - 2015 26376879

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine         liver         Lymphoid/Immune spleen         Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , tetramer

HOMOLOGY

interspecies

homolog to murine Aldo2

Homologene

FAMILY

class I fructose-bisphosphate aldolase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,lysosome
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	catalyzing the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate
	ALDOC, ALDOA and ALDOB activate Wnt signaling in a GSK3B-dependent mechanism
	expression of ALDOB in islets is negatively associated with insulin secretion

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate , energetic

signaling

	glycolysis
	fructose metabolism

a component

INTERACTION

DNA

RNA

small molecule

protein	PDIA3 appeared to be a negative effector of SLC28A2 function, whereas ALDOB flux modulated SLC28A2 activity via a mechanism involving acquisition of higher affinity for its substrates
	FBP1 guides the cellular localization of ALDOB

cell & other

REGULATION

induced by

after feeding a carbohydrate diet

ASSOCIATED DISORDERS

corresponding disease(s)

ALDOB

related resource

Hereditary Fructose Intolerance/Aldolase

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   promotes colorectal cancer metastasis by facilitating EMT

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may be a new biomarker associated with mismatch repair (MMR) defieciency and an independent prognostic factor for colon adenocarcinoma
	biomarker in colorectal cancer
Therapy target
	System Type Disorder Pubmed cancer digestive liver therapeutic target in colorectal cancer

ANIMAL & CELL MODELS