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FLASH GENE
Symbol ALDOB contributors: mct - updated : 28-11-2019
HGNC name aldolase B, fructose-bisphosphate
HGNC id 417
Corresponding disease
ALDOB fructose intolerance, hereditary
Location 9q31.1      Physical location : 104.182.841 - 104.198.062
Synonym name
  • liver-type aldolase
  • aldolase 2
  • aldolase B, fructose-bisphosphate
  • liver-type aldolase
    • Synonym symbol(s) ALFB, ALDO2, ALDB
    EC.number 4.1.2.13
    DNA
    TYPE functioning gene
    STRUCTURE 14.45 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see BAAT
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2426 - 364 - 2015 26376879
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     liver    
    Lymphoid/Immunespleen    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to murine Aldo2
    Homologene
    FAMILY
  • class I fructose-bisphosphate aldolase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • catalyzing the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate
  • ALDOC, ALDOA and ALDOB activate Wnt signaling in a GSK3B-dependent mechanism
  • expression of ALDOB in islets is negatively associated with insulin secretion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate , energetic
    signaling
  • glycolysis
  • fructose metabolism
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDIA3 appeared to be a negative effector of SLC28A2 function, whereas ALDOB flux modulated SLC28A2 activity via a mechanism involving acquisition of higher affinity for its substrates
  • FBP1 guides the cellular localization of ALDOB
    • cell & other
    REGULATION
    induced by after feeding a carbohydrate diet
    ASSOCIATED DISORDERS
    corresponding disease(s) ALDOB
    related resource Hereditary Fructose Intolerance/Aldolase
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    promotes colorectal cancer metastasis by facilitating EMT
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be a new biomarker associated with mismatch repair (MMR) defieciency and an independent prognostic factor for colon adenocarcinoma
  • biomarker in colorectal cancer
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    therapeutic target in colorectal cancer
    ANIMAL & CELL MODELS