Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol C1QB contributors: mct/npt - updated : 21-09-2009
HGNC name complement component 1, q subcomponent, B chain
HGNC id 1242
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a globular head,
  • a collagen-like domain
  • a C terminal carbohydrate binding domain, forming a disulfide-linked dimer with C1QA
  • a C1Q-domain
    • mono polymer monomer
    HOMOLOGY
    intraspecies homolog to non collagen-like sequence of COLVIII and COLX
    Homologene
    FAMILY
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • classical pathway of C3 activation
  • induces maturation of human dendritic cells (Csomor 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a disulfide linked dimer with a C1QA
  • part of the C1 complex including six C1QA, six C1QB, six C1QG
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • AGER is a native C1QA, C1QB, C1QC globular domain receptor (C1q and AGER are linked to the recruitment of leukocytes and phagocytosis of C1q-coated material)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) C1QB
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS