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FLASH GENE

Symbol

C1QB

contributors: mct/npt - updated : 21-09-2009

HGNC name	complement component 1, q subcomponent, B chain
HGNC id	1242

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	8.35 kb     3 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Text

see C1Q@

regionally located

clustered with C1QA, C1QG in the order 5' - A, C(G), B - 3'

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000491 3 - 1044 NP_000482 26.6 253 - Marquart (2007)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach       highly Endocrine adrenal gland       highly Lymphoid/Immune spleen       highly

cell lineage
cell lines
fluid/secretion	serum

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a globular head,
	a collagen-like domain
	a C terminal carbohydrate binding domain, forming a disulfide-linked dimer with C1QA
	a C1Q-domain

mono polymer

monomer

HOMOLOGY

intraspecies

homolog to non collagen-like sequence of COLVIII and COLX

Homologene

FAMILY

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	classical pathway of C3 activation
	induces maturation of human dendritic cells (Csomor 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	forming a disulfide linked dimer with a C1QA
	part of the C1 complex including six C1QA, six C1QB, six C1QG

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein

AGER is a native C1QA, C1QB, C1QC globular domain receptor (C1q and AGER are linked to the recruitment of leukocytes and phagocytosis of C1q-coated material)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

C1QB

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS