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FLASH GENE

Symbol

ACHE

contributors: mlc/npt/pgu - updated : 19-09-2023

HGNC name	acetylcholinesterase (Yt blood group)
HGNC id	108

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

YT

related resource

Blood Group Antigen Mutation Database

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in Alzheimer disease (AD) decrease in the enzymatic activity of the enzyme acetylcholinesterase

Susceptibility

to neurodegenerative diseases

Variant & Polymorphism other	variants putatively involved in neurodegenerative diseases

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative alzheimer AChE) enzyme inhibition is an important target for the management of Alzheimer disease (AD) and ACHE inhibitors are the main stay drugs for its management neurology neurodegenerative alzheimer Acetylcholinesterase (AChE) has obtained a renewed interest as a therapeutic target in Alzheimer's disease (AD) due to increased neural cells' function by increasing the concentration of acetylcholine

ANIMAL & CELL MODELS

significant decrease in trabecular perimeter of lumbar vertebrae and cortical area fraction (Ct.Ar/Tt.Ar) in the mid-diaphysis of femurs of AChE-KO mice compared to their WT