| SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,nucleus
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| intracellular,nuclear envelope
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| text
| membrane |
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the catalytic subunits of acetylcholinesterase (ACHE) are anchored in the basal lamina of the neuromuscular junction using a collagen-like tail subunit (ColQ) encoded by COLQ  |
| basic FUNCTION
| responsible for the hydrolysis of the neurotransmitter acetylcholine and therefore the termination of the neural impulse |
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involved in the signal transmission at neuromuscular junction |
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hydrolyzing the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission |
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associates differently with its anchoring proteins COLQ and PRiMA1 |
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terminates signal transmission at chemical synapses by degrading the neurotransmitter acetylcholine and was found to play a role in plaque formation in Alzheimer disease |
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responsible for the hydrolysis of the neurotransmitter, acetylcholine, in the nervous system |
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implicated in the pathogenesis of Alzheimer disease (AD) and it has been shown that it accelerates formation and increases toxicity of amyloid fibrils, which have been closely linked to the pathology of AD |
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can be considered a highly co-opting protein, which can combine enzymatic and non-enzymatic functions within one molecule |
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ACHE is a cholinergic and agrin a synaptogenetic component of the neuromuscular junction |
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common features of ACHE and agrin extend to their capacity to play multiple roles in muscle development |
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ACHE hydrolyzes acetylcholine (ACh) to acetate and choline and thereby terminates nerve impulse transmission |
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role of ACHE in erythroblast maturation, which provided an insight in elucidating possible mechanisms in regulating erythropoiesis |
