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FLASH GENE
Symbol SURF4 contributors: mct - updated : 21-06-2017
HGNC name surfeit 4
HGNC id 11476
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments
  • a predicted lumenal N terminus
  • multiple phosphorylation sites and a double-lysine retrieval motif at the C terminus
    • HOMOLOGY
    interspecies ortholog to murine Surf4
    homolog to Drosophila Surf4
    ortholog to yeast cargo receptor Erv29p
    Homologene
    FAMILY
  • SURF4 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • SURF4 associated with STIM1 in the endoplasmic reticulum
    • basic FUNCTION
  • may be required for packaging glycosylated pro-alpha-factor into COPII vesicles
  • modulatory function of SURF4 for STIM1-mediated Store-operated Ca(2+) entry
  • SURF4 modulate STIM1 puncta formation and/or relocation to the ER–Plasma membrane (PM) junctions
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SURF4 associated with STIM1 in the endoplasmic reticulum, and is a STIM1 binding partner
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS