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FLASH GENE

Symbol

SURF4

contributors: mct - updated : 21-06-2017

HGNC name	surfeit 4
HGNC id	11476

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	16.50 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map

see SURF@

regionally located

mapped to the telomeric end of the surfeit cluster

RNA

TRANSCRIPTS	type	messenger

text	transcript length variation resulting from the use of multiple polyadenylation sites

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_033161 6 splicing 3068 NP_149351 30.4 269 - 2008 18287528 NM_001280788 6 splicing 2923 NP_001267717 - 254 - 2008 18287528 NM_001280789 6 - 2709 NP_001267718 - 159 - 2008 18287528 NM_001280792 5 - 2881 NP_001267721 - 128 - 2008 18287528 NM_001280793 5 - 2991 NP_001267722 - 152 - 2008 18287528 NM_001280790 7 - 3218 NP_001267719 - 226 - 2008 18287528 NM_001280791 6 - 3166 NP_001267720 - 226 - 2008 18287528

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	seven transmembrane segments
	a predicted lumenal N terminus
	multiple phosphorylation sites and a double-lysine retrieval motif at the C terminus

HOMOLOGY

interspecies	ortholog to murine Surf4
	homolog to Drosophila Surf4
	ortholog to yeast cargo receptor Erv29p

Homologene

FAMILY

SURF4 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
text	SURF4 associated with STIM1 in the endoplasmic reticulum

basic FUNCTION	may be required for packaging glycosylated pro-alpha-factor into COPII vesicles
	modulatory function of SURF4 for STIM1-mediated Store-operated Ca(2+) entry
	SURF4 modulate STIM1 puncta formation and/or relocation to the ER–Plasma membrane (PM) junctions

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	SURF4 associated with STIM1 in the endoplasmic reticulum, and is a STIM1 binding partner

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gastric cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS