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FLASH GENE

Symbol

HOXA13

contributors: mct - updated : 28-03-2016

HGNC name	homeo box A13
HGNC id	5102

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HFG , GTMS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       in hypodactyly mutants tumoral fusion       fused with NUP98 int (7;11) (p15;p15) in acute myeloid leukemia constitutional       loss of function severely disrupts embryonic limb development

Susceptibility

Variant & Polymorphism repeat	polyalanine repeat expansion associated with HFG

Candidate gene
Marker	is a negative independent predictor of disease-free survival of patients with esophageal squamous cell carcinoma
Therapy target

ANIMAL & CELL MODELS

	defects in interdigital programmed cell death (IPCD) and digit separation in Hoxa13 mutant mice may be caused in part by reduced levels of retinoic acid
	loss of Hoxa13 and Hoxd13 transcription factors (Hox13) leads to digit agenesis in mice