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FLASH GENE
Symbol HOXA11 contributors: mct - updated : 02-02-2011
HGNC name homeobox A11
HGNC id 5101
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an homeobox DNA binding domain
  • helix-turn-helix
    • HOMOLOGY
    interspecies homolog to murine Hoxa11 (98.1 pc)
    homolog to zebrafish hoxa11b (76 pc)
    Homologene
    FAMILY
  • ABD-B homeobox family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in the regulation of uterine development
  • required for female fertility
  • playing a role in the developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
  • essential for organogenesis of the uterosacral ligaments
  • required for prolactin expression in decidualized endometrial stromal cells
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text morphogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • physical association of HOXA11 and FOXO1, and binding of both factors to an enhancer region of the decidual prolactin promoter
    • cell & other
    REGULATION
    inhibited by YY1 via direct physical interaction
    Other spatially and temporally regulated during embryonic development
    ASSOCIATED DISORDERS
    corresponding disease(s) RUSAT
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion translocation    
    fused with NUP98 in t(7;11) (p15;p15) in chronic myeloid leukemia (in acute leukemia phase)
    constitutional     --low  
    with both collagens (collagen type I, collagen type III) was dramatically decreased in women with pelvic organ prolapse
    tumoral     --other  
    its DNA methylation was independently associated with poor outcome in ovarian cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS